Propofol vs Sevoflurane in General and Cognitive Recovery from Anaesthesia in Day Care Surgery- A Randomised Clinical Trial
Published: December 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/46068.14349
Gurpreet Singh, Haramritpal Kaur, Saravana Kumar, Amandeep Singh, Chandni Maheshwari, Jatin Gupta, Vimal Prasad, Sai Charan Karne
1. Professor, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
2. Associate Professor, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
3. Senior Resident, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
4. Associate Professor, Department of Surgery, GGS Medical College and Hospital, Faridkot, Punjab, India.
5. Assistant Professor, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
6. Junior Resident, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
7. Junior Resident, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
8. Junior Resident, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
Correspondence
Haramritpal Kaur,
Associate Professor, Department of Anaesthesia, GGS Medical College and Hospital, Faridkot, Punjab, India.
E-mail: amritk_dr@yahoo.co.in
Introduction: Rapid emergence from anaesthesia and postoperative recovery of cognitive function is one of the most important requirements of a day care surgery. Propofol is a nearideal intravenous anaesthetic agent for day care surgeries due to its pharmacological properties. Similarly, amongst inhalational anaesthetic agents, sevoflurane is the preferred agent due to low blood-gas solubility.
Aim: To evaluate sevoflurane and propofol for general and psychomotor recovery profile in day care anaesthesia techniques.
Materials and Methods: This randomised clinical trial was conducted at GGS Medical College and Hospital, Faridkot, Punjab after getting approval by Institutional Ethical Committee. A total of 70 American society of Anaesthesiologists’ (ASA) Grade I and II patients aged 18-60 years, scheduled to undergo elective day care surgery under general anaesthesia were enrolled. In group A (n=35) anaesthesia was induced with propofol 2 mg/kg intravenously and maintained with variable-rate propofol infusion. In group B (n=35) anaesthesia was induced with sevoflurane 8% and maintained with sevoflurane. In both the groups general {mean time to remove Laryngeal Mask Airway (LMA), emergence, time to responds to commands, mean orientation time} and psychomotor recovery profile was evaluated using unpaired student’s t-test and Chi-square test.
Results: Mean Time to remove LMA in Group B was earlier being 5.30 ±1.23 minutes vs 8.65 ±2.40 minutes in group A (p<0.001). Mean emergence time in Group B was 5.83 ±1.23 minutes and in Group A was 8.87±2.42 minutes (p<0.001). Time to respond to commands in Group B was 6.81 ±1.39 minutes and in Group A was 10.01 ±2.52 minutes (p<0.001). Mean Orientation time in Group B was 7.15 ±1.53 minutes and in Group A was 10.76±2.61 minutes (p<0.001). Psychomotor recovery was also faster with sevoflurane as compared to propofol.
Conclusion: Both sevoflurane and propofol are useful agents for day care surgery. Sevoflurane provides a rapid return of psychomotor and cognitive ability as compared to propofol.
[
FULL TEXT ] | [ PDF]